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Amitriptyline And Alcohol. Amitriptyline And Alcohol. Five healthy volunteers received 25 mg of amitriptyline orally preceded by one hour and followed for eight hours by oral ethanol or juice dosed to achieve and maintain blood ethanol concentrations of 800 mgl.
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Mixing amitriptyline and alcohol can increase the chances of experiencing negative side effects from the medication. The type of DDI that will be produced when Amitriptyline and Alcohol are co-administered will depend on the degree of Alcohol use. It just says that it will increase the risk of drowsiness.
Alcohol increases the sedative effects of amitriptyline.
Amitriptyline makes you sleepy which alcohol can do too so be careful driving or using heavy machinery does an iron count Patientcouk says. It just says that it will increase the risk of drowsiness. All I can find is not to drink when its prescribed for depression. A low dose of 10mg.
